Carboxylic acids and derivatives
Apexbio Technology LLC Rigosertib sodium salt 1225497-78-8 25mg
Rigosertib sodium salt (CAS 1225497-78-8) is a selective inhibitor targeting Polo-like kinase 1 (PLK1) with reported IC50 approximately 9 nM The compound notably decreases proliferation of cancer cell lines demonstrating nanomolar IC50 values in HeLa (115 nM) and C33A (45 nM) cells whereas normal cells (e g BJ and Ect1/E6E7) remain largely unaffected At concentrations exceeding 0 5 M rigosertib robustly induces G2/M phase arrest in cancer cells without significant cell cycle disruption at lower doses Additionally in vivo studies suggest its potential as a radiosensitizer in cervical carcinoma research
Apexbio Technology LLC Nigericin sodium salt 28643-80-3 50 mg
Nigericin sodium salt is a lipid-soluble ionophore functioning by facilitating K /H exchange across biological membranes Experimentally it modulates intracellular pH levels through its ion-transport activity influencing cellular processes sensitive to pH homeostasis such as platelet aggregation and energy metabolism pathways Nigericin exhibits limited inhibitory effects on platelet aggregation induced by agonists like thrombin or ADP correlating primarily with reductions in cytoplasmic pH Additionally nigericin has demonstrated capacity to transport Pb2 ions across membranes selectively suggesting potential utility in experimental models targeting metal ion homeostasis and heavy-metal toxicity research Nigericin exhibits inhibitory activity on ATP-driven transhydrogenase reactions showing varied IC50 depending upon ATP concentrations and experimental conditions (IC50 values typically range from low micromolar to submillimolar concentrations)
Apexbio Technology LLC Rigosertib sodium salt 1225497-78-8 100mg
Rigosertib sodium salt (CAS 1225497-78-8) is a selective inhibitor targeting Polo-like kinase 1 (PLK1) with reported IC50 approximately 9 nM The compound notably decreases proliferation of cancer cell lines demonstrating nanomolar IC50 values in HeLa (115 nM) and C33A (45 nM) cells whereas normal cells (e g BJ and Ect1/E6E7) remain largely unaffected At concentrations exceeding 0 5 M rigosertib robustly induces G2/M phase arrest in cancer cells without significant cell cycle disruption at lower doses Additionally in vivo studies suggest its potential as a radiosensitizer in cervical carcinoma research
Apexbio Technology LLC Methicillin (sodium salt) 132-92-3 100mg
Methicillin sodium salt is a semisynthetic antibiotic belonging to the penicillin class characterized by inhibition of bacterial cell wall synthesis It exerts bactericidal activity by binding covalently to bacterial transpeptidases (penicillin-binding proteins PBPs) disrupting peptidoglycan cross-link formation and compromising cell wall integrity Methicillin has been employed in research primarily against gram-positive bacteria including penicillinase-producing strains such as Staphylococcus aureus Experimentally methicillin can serve as a reference compound in vitro studies evaluating antimicrobial susceptibility or resistance mechanisms The minimum inhibitory concentration (MIC) values reported typically range between 0 5 to 4 g/mL depending upon bacterial strain and experimental conditions Currently its primary use is confined to laboratory research due to availability of alternative penicillin derivatives
